Enoil-(acil-nosilac-protein) reduktaza (NADPH, B-specifična)
| Enoil-(acil-nosilac-protein) reduktaza (NADPH, B-specifična) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.3.1.10 | ||||||||
| CAS broj | 37251-09-5 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Enoil-(acil-nosilac-protein) reduktaza (NADPH, B-specifična) (EC 1.3.1.10, acil-ACP dehidrogenaza, reduktaza, enoil-(acil nosilac protein) (redukovani nikotinamid adenin dinukleotid fosfat), NADPH 2-enoil Co A reduktaza, enoil acil-nosilac-protein reduktaza, enoil-ACP reduktaza, acil-(acil-nosilac-protein):NADP+ oksidoreduktaza (B-specifična)) je enzim sa sistematskim imenom acil-(acil-nosilac protein):NADP+ oksidoreduktaza (B-specifična).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- acil-[acil-nosilac protein] + NADP+ trans-2,3-dehidroacil-[acil-nosilac protein] + NADPH + H+
Ovaj enzim katalizuje redukciju enoil-acil-[acil-nosilac protein] derivata sa ugljeničnim lancom dužine 4 do 16 atoma. Enzim kvasca i Escherichia coli su B-specifični u pogledu NADP+ (cf. EC 1.3.1.39 enoil-[acil-nosilac-protein] reduktaza (NADPH specifična)).
Reference[uredi | uredi kod]
- ↑ Saito, K., Kawaguchi, A., Okuda, S., Seyama, Y. and Yamakawa, T. (1980). „Incorporation of hydrogen atoms from deuterated water and stereospecifically deuterium-labeled nicotinamide nucleotides into fatty acids with the Escherichia coli fatty acid synthetase system”. Biochim. Biophys. Acta 618: 202-213. PMID 6990992.
- ↑ Seyama, T., Kasama, T., Yamakawa, T., Kawaguchi, A., Saito, K. and Okuda, S. (1977). „Origin of hydrogen atoms in the fatty acids synthesized with yeast fatty acid synthetase”. J. Biochem. (Tokyo) 82: 1325-1329. PMID 338601.
- ↑ Weeks, G. and Wakil, S.J. (1968). „Studies on the mechanism of fatty acid synthesis. 18. Preparation and general properties of the enoyl acyl carrier protein reductases from Escherichia coli”. J. Biol. Chem. 243: 1180-1189. PMID 4384650.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.