9-cis-epoksikarotenoid dioksigenaza
(Preusmjereno sa stranice EC 1.13.11.51)
| 9-cis-epoksikarotenoid dioksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.13.11.51 | ||||||||
| CAS broj | 199877-10-6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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9-cis-epoksikarotenoid dioksigenaza (EC 1.13.11.51, devet-cis-epoksikarotenoidna dioksigenaza, NCED, AtNCED3, PvNCED1, VP14) je enzim sa sistematskim imenom 9-cis-epoksikarotenoid 11,12-dioksigenaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (1) 9-cis-epoksikarotenoid + O2 2-cis,4-trans-ksantoksin + a 12'-apo-karotenal
- (2) 9-cis-violaksantin + O2 2-cis,4-trans-ksantoksin + (3S,5R,6S)-5,6-epoksi-3-hidroksi-5,6-dihidro-12'-apo-beta-karoten-12'-al
- (3) 9'-cis-neoksantin + O2 2-cis,4-trans-ksantoksin + (3S,5R,6R)-5,6-dihidroksi-6,7-didehidro-5,6-dihidro-12'-apo-beta-karoten-12'-al
Ovaj enzim sadrži gvožđe(II). On deluje na 9-cis-violaksantin i 9'-cis-neoksantin.
Reference[uredi | uredi kod]
- ↑ Schwartz, S.H., Tan, B.C., Gage, D.A., Zeevaart, J.A. and McCarty, D.R. (1997). „Specific oxidative cleavage of carotenoids by VP14 of maize”. Science 276: 1872-1874. PMID 9188535.
- ↑ Tan, B.C., Schwartz, S.H., Zeevaart, J.A. and McCarty, D.R. (1997). „Genetic control of abscisic acid biosynthesis in maize”. Proc. Natl. Acad. Sci. USA 94: 12235-12240. PMID 9342392.
- ↑ Qin, X. and Zeevaart, J.A. (1999). „The 9-cis-epoxycarotenoid cleavage reaction is the key regulatory step of abscisic acid biosynthesis in water-stressed bean”. Proc. Natl. Acad. Sci. USA 96: 15354-15361. PMID 10611388.
- ↑ Thompson, A.J., Jackson, A.C., Symonds, R.C., Mulholland, B.J., Dadswell, A.R., Blake, P.S., Burbidge, A. and Taylor, I.B. (2000). „Ectopic expression of a tomato 9-cis-epoxycarotenoid dioxygenase gene causes over-production of abscisic acid”. Plant J. 23: 363-374. PMID 10929129.
- ↑ Iuchi, S., Kobayashi, M., Taji, T., Naramoto, M., Seki, M., Kato, T., Tabata, S., Kakubari, Y., Yamaguchi-Shinozaki, K. and Shinozaki, K. (2001). „Regulation of drought tolerance by gene manipulation of 9-cis-epoxycarotenoid dioxygenase, a key enzyme in abscisic acid biosynthesis in Arabidopsis”. Plant J. 27: 325-333. PMID 11532178.
- ↑ Iuchi, S., Kobayashi, M., Taji, T., Naramoto, M., Seki, M., Kato, T., Tabata, S., Kakubari, Y., Yamaguchi-Shinozaki, K. and Shinozaki, K. (2002). „Regulation of drought tolerance by gene manipulation of 9-cis-epoxycarotenoid dioxygenase, a key enzyme in abscisic acid biosynthesis in Arabidopsis”. Plant J. 30: 611-611.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
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