Dihidrokaempferol 4-reduktaza
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| Dihidrokaempferol 4-reduktaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.1.219 | ||||||||
| CAS broj | 83682-99-9 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Dihidrokaempferol 4-reduktaza (EC 1.1.1.219, dihidroflavanol 4-reduktaza, dihidromiricetinska reduktaza, NADPH-dihidromiricetinska reduktaza, dihidrokvercetin reduktaza) je enzim sa sistematskim imenom cis-3,4-leuopelargonidin:NADP+ 4-oksidoreduktaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- cis-3,4-leukopelargonidin + NADP+ (+)-dihidrokemferol + NADPH + H+
Takođe deluje, u reverznom smeru, na (+)-dihidrokvercetin i (+)-dihidromiricetin. Svaki dihidroflavonol se redukuje do korespondirajućeg cis-flavan-3,4-diola. Može da koristi NAD[3] umesto NADP+, mada reakcija sporo teče. Dihidrokaempferolna 4-reduktaza učestvuje u biosintezi antocijanidina u biljkama.
Reference[uredi | uredi kod]
- ↑ Heller, W., Forkmann, G., Britsch, L. and Grisebach, H. (1985). „Enzymatic reduction of (+)-dihydroflavonols to flavan-3,4-cis- diols with flower extracts from Matthiola incana and its role in anthocyanin biosynthesis”. Planta 165: 284-287.
- ↑ Stafford, H.A. and Lester, H.H. (1985). „Flavan-3-ol biosynthesis the conversion of (+)- dihydromyricetin to its flavan-3,4-diol (leucodelphinidin) and to (+)-gallocatechin by reductases extracted from tissue-cultures of Ginkgo biloba and Pseudotsuga-menziesii”. Plant Physiol. 78: 791-794. PMID 16664326.
- ↑ +
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.