Diacilglicerol difosfatna fosfataza
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| Diacilglicerol difosfatna fosfataza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.1.3.81 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Diacilglicerol difosfatna fosfataza (EC 3.1.3.81, DGPP fosfataza, DGPP fosfohidrolaza, DPP1, DPPL1, DPPL2, PAP2, pirofosfatna fosfataza) je enzim sa sistematskim imenom 1,2-diacil-sn-glicerol 3-fosfat fosfohidrolaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 1,2-diacil-sn-glicerol 3-difosfat + H2O 1,2-diacil-sn-glicerol 3-fosfat + fosfat
Ovaj bifunkcionalni enzim katalizuje defosforilaciju diacilglicerol difosfata do fosfatidata i naknadnu defosforilaciju fosfatidata do diacilglicerola.
Reference[uredi | uredi kod]
- ↑ Dillon, D.A., Wu, W.I., Riedel, B., Wissing, J.B., Dowhan, W. and Carman, G.M. (1996). „The Escherichia coli pgpB gene encodes for a diacylglycerol pyrophosphate phosphatase activity”. J. Biol. Chem. 271: 30548-30553. PMID 8940025.
- ↑ Dillon, D.A., Chen, X., Zeimetz, G.M., Wu, W.I., Waggoner, D.W., Dewald, J., Brindley, D.N. and Carman, G.M. (1997). „Mammalian Mg2+-independent phosphatidate phosphatase (PAP2) displays diacylglycerol pyrophosphate phosphatase activity”. J. Biol. Chem. 272: 10361-10366. PMID 9099673.
- ↑ Wu, W.I., Liu, Y., Riedel, B., Wissing, J.B., Fischl, A.S. and Carman, G.M. (1996). „Purification and characterization of diacylglycerol pyrophosphate phosphatase from Saccharomyces cerevisiae”. J. Biol. Chem. 271: 1868-1876. PMID 8567632.
- ↑ Oshiro, J., Han, G.S. and Carman, G.M. (2003). „Diacylglycerol pyrophosphate phosphatase in Saccharomyces cerevisiae”. Biochim. Biophys. Acta 1635: 1-9. PMID 14642771.
- ↑ Carman, G.M. (1997). „Phosphatidate phosphatases and diacylglycerol pyrophosphate phosphatases in Saccharomyces cerevisiae and Escherichia coli”. Biochim. Biophys. Acta 1348: 45-55. PMID 9370315.
- ↑ Han, G.S., Johnston, C.N., Chen, X., Athenstaedt, K., Daum, G. and Carman, G.M. (2001). „Regulation of the Saccharomyces cerevisiae DPP1-encoded diacylglycerol pyrophosphate phosphatase by zinc”. J. Biol. Chem. 276: 10126-10133. PMID 11139591.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.