Delta8-masna-kiselina desaturaza

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Delta8-masna-kiselina desaturaza
Identifikatori
EC broj 1.14.19.4
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB RCSB PDB PDBe PDBj PDBsum

Delta8-masna-kiselina desaturaza (EC 1.14.19.4, Delta8-sfingolipidna desaturaza, EFD1, BoDES8, SLD, Delta8 masno kiselinska desaturaza, Delta8-desaturaza) je enzim sa sistematskim imenom fitosfinganin,vodonik donor:kiseonik Delta8-oksidoreduktaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju

fitosfinganin + redukovani akceptor + O2 Delta8-fitosfingenin + akceptor + 2H2O

Ovaj enzim je prisutan u mnogim biljkama. On uvodi dvostruku vezu u Delta8 kod C18 i C20 masnih kiselina.

Reference[uredi | uredi kod]

  1. Wallis, J.G. and Browse, J. (1999). „The Δ8-desaturase of Euglena gracilis: an alternate pathway for synthesis of 20-carbon polyunsaturated fatty acids”. Arch. Biochem. Biophys. 365: 307-316. PMID 10328826. 
  2. Sperling, P., Libisch, B., Zähringer, U., Napier, J.A. and Heinz, E. (2001). „Functional identification of a Δ8-sphingolipid desaturase from Borago officinalis”. Arch. Biochem. Biophys. 388: 293-298. PMID 11368168. 
  3. Takakuwa, N., Kinoshita, M., Oda, Y. and Ohnishi, M. (2002). „Isolation and characterization of the genes encoding Δ8-sphingolipid desaturase from Saccharomyces kluyveri and Kluyveromyces lactis'”. Curr. Microbiol. 45: 459-461. PMID 12402089. 
  4. Beckmann, C., Rattke, J., Oldham, N.J., Sperling, P., Heinz, E. and Boland, W. (2002). „Characterization of a Δ8-sphingolipid desaturase from higher plants: a stereochemical and mechanistic study on the origin of E,Z isomers”. Angew. Chem. Int. Ed. Engl. 41: 2298-2300. PMID 12203571. 

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