DNK-(apurinsko ili apirimidinsko mesto) lijaza
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| DNK-(apurinsko ili apirimidinsko mesto) lijaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.99.18 | ||||||||
| CAS broj | 61811-29-8 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
DNK-(apurinsko ili apirimidinsko mesto) lijaza (EC 4.2.99.18, AP lijaza, AP endonukleaza klasa I, endodezoksiribonukleaza (apurinska ili apirimidinska), dezoksiribonukleaza (apurinska ili apirimidinska), E. coli endonukleaza III, fag-T4 UV endonukleaza, Micrococcus luteus UV endonukleaza, AP mesto-DNK 5'-fosfomonoestar-lijaza, X-zrak endonukleaza III) je enzim sa sistematskim imenom DNK-(apurinsko ili apirimidinsko mesto) 5'-fosfomonoestar-lijaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- C-O-P veza 3' vezana za apurinsko ili apirimidinsko mesto u DNK se razlaže reakcijom beta-eliminacije, čime se formira 3'-terminalno nezasićeni šećer i produkt sa terminalnim 5'-fosfatom
Ova grupa enzima se ranije smatrala endonukleazama.
Reference[uredi | uredi kod]
- ↑ Bailly, V., Sente, B. and Verly, W.G. (1989). „Bacteriophage-T4 and Micrococcus luteus UV endonucleases are not endonucleases but β-elimination and sometimes -elimination catalysts”. Biochem. J. 259: 751-759. PMID 2471512.
- ↑ Bailly, V. and Verly, W.G. (1987). „Escherichia coli endonuclease III is not an endonuclease but a β-elimination catalyst”. Biochem. J. 242: 565-572. PMID 2439070.
- ↑ Bailly, V. and Verly, W.G. (1989). „AP endonucleases and AP lyases”. Nucleic Acids Res. 17: 3617-3618. PMID 2471157.
- ↑ Manoharan, M., Mazumder, A., Ransom, S.C., Gerlt, J.A. and Bolton, P.H. (1988). „Mechanism of UV endonuclease-V cleavage of abasic sites in DNA determined by C-13 labeling”. J. Am. Chem. Soc. 110: 2690-2691.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.