Serin-tip D-Ala-D-Ala karboksipeptidaza
(Preusmjereno sa stranice DD-transpeptidaza)
| Serin-tip D-Ala-D-Ala karboksipeptidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.16.4 | ||||||||
| CAS broj | 9077-67-2 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Serin-tip D-Ala-D-Ala karboksipeptidaza (EC 3.4.16.4, DD-peptidaza, D-alanil-D-alanin-karboksipeptidaza, D-alanil-D-alanin-razlažuća-peptidaza, D-alanil-D-alanin-razlažuća peptidaza, DD-transpeptidaza, D-alaninska karboksipeptidaza, DD-karboksipeptidaza, D-alanilna karboksipeptidaza) je enzim.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Preferenciono razlaganje: (Ac)2-L-Lys-D-Ala--D-Ala. Takođe transpeptidacija peptidil-alanil grupa koje su N-acil supstituenti D-alanina
Ovaj membranski bakterijski enzim inhibira penicilin i drugi beta-laktamski antibiotici.
Reference[uredi | uredi kod]
- ↑ Ghuysen, J.-M., Frère, J.-M., Leyh-Bouille, M., Nguyen-Distèche, M., Coyette, J., Dusart, J., Joris, B., Duez, C., Dideberg, O., Charlier, P., Dive, G. and Lamotte-Brasseur, J. (1984). „Bacterial wall peptidoglycan, DD-peptidases and β-lactam antibiotics”. Scand. J. Infect. Dis. Suppl. 42: 17-37. PMID 6597561.
- ↑ Frère, J.M. and Joris, B. (1985). „Penicillin-sensitive enzymes in peptidoglycan biosynthesis”. CRC Crit. Rev. Microbiol. 11: 306-331. PMID 3888533.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.