D-ksiloza reduktaza

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D-ksiloza reduktaza
Identifikatori
EC broj 1.1.1.307
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

D-ksiloza reduktaza (EC 1.1.1.307, XylR, XyrA, msXR, dsXR, monospecifična ksilozna reduktaza, dualno specifična ksilozna reduktaza, NAD(P)H-zavisna ksilozna reduktaza, ksilozma reduktaza) je enzim sa sistematskim imenom ksilitol:NAD(P)+ oksidoreduktaza.[1][2][3][4][5][6][7][8] Ovaj enzim katalizuje sledeću hemijsku reakciju

ksilitol + NAD(P)+ \rightleftharpoons D-ksiloza + NAD(P)H + H+

Ksilozna reduktaza katalizuje inicijalnu reakcija u metaboličkom putu koji koristi ksilozu. Dolazi do NAD(P)H zavisne redukcija ksiloze do ksilitola.

Reference[uredi - уреди]

  1. Neuhauser, W., Haltrich, D., Kulbe, K.D. and Nidetzky, B. (1997). "NAD(P)H-dependent aldose reductase from the xylose-assimilating yeast Candida tenuis. Isolation, characterization and biochemical properties of the enzyme". Biochem. J. 326: 683–692. PMID 9307017. 
  2. Nidetzky, B., Bruggler, K., Kratzer, R. and Mayr, P. (2003). "Multiple forms of xylose reductase in Candida intermedia: comparison of their functional properties using quantitative structure-activity relationships, steady-state kinetic analysis, and pH studies". J. Agric. Food Chem. 51: 7930–7935. PMID 14690376. 
  3. Iablochkova, E.N., Bolotnikova, O.I., Mikhailova, N.P., Nemova, N.N. and Ginak, A.I. (2003). "The activity of xylose reductase and xylitol dehydrogenase in yeasts". Mikrobiologiia 72: 466–469. PMID 14526534. 
  4. Chen, L.C., Huang, S.C., Chuankhayan, P., Chen, C.D., Huang, Y.C., Jeyakanthan, J., Pang, H.F., Men, L.C., Chen, Y.C., Wang, Y.K., Liu, M.Y., Wu, T.K. and Chen, C.J. (2009). "Purification, crystallization and preliminary X-ray crystallographic analysis of xylose reductase from Candida tropicalis". Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 65: 419–421. PMID 19342796. 
  5. Verduyn, C., Van Kleef, R., Frank, J., Schreuder, H., Van Dijken, J.P. and Scheffers, W.A. (1985). "Properties of the NAD(P)H-dependent xylose reductase from the xylose-fermenting yeast Pichia stipitis". Biochem. J. 226: 669–677. PMID 3921014. 
  6. Fernandes, S., Tuohy, M.G. and Murray, P.G. (2009). "Xylose reductase from the thermophilic fungus Talaromyces emersonii: cloning and heterologous expression of the native gene (Texr) and a double mutant (TexrK271R + N273D) with altered coenzyme specificity". J. Biosci. 34: 881–890. PMID 20093741. 
  7. Lee, J.K., Koo, B.S. and Kim, S.Y. (2003). "Cloning and characterization of the xyl1 gene, encoding an NADH-preferring xylose reductase from Candida parapsilosis, and its functional expression in Candida tropicalis". Appl. Environ. Microbiol. 69: 6179–6188. PMID 14532079. 
  8. Woodyer, R., Simurdiak, M., van der Donk, W.A. and Zhao, H. (2005). "Heterologous expression, purification, and characterization of a highly active xylose reductase from Neurospora crassa". Appl. Environ. Microbiol. 71: 1642–1647. PMID 15746370. 

Literatura[uredi - уреди]

Spoljašnje veze[uredi - уреди]