D-ksiloza reduktaza
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| D-ksiloza reduktaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.1.307 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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D-ksiloza reduktaza (EC 1.1.1.307, XylR, XyrA, msXR, dsXR, monospecifična ksilozna reduktaza, dualno specifična ksilozna reduktaza, NAD(P)H-zavisna ksilozna reduktaza, ksilozma reduktaza) je enzim sa sistematskim imenom ksilitol:NAD(P)+ oksidoreduktaza.[1][2][3][4][5][6][7][8] Ovaj enzim katalizuje sledeću hemijsku reakciju
- ksilitol + NAD(P)+ D-ksiloza + NAD(P)H + H+
Ksilozna reduktaza katalizuje inicijalnu reakcija u metaboličkom putu koji koristi ksilozu. Dolazi do NAD(P)H zavisne redukcija ksiloze do ksilitola.
Reference[uredi | uredi kod]
- ↑ Neuhauser, W., Haltrich, D., Kulbe, K.D. and Nidetzky, B. (1997). „NAD(P)H-dependent aldose reductase from the xylose-assimilating yeast Candida tenuis. Isolation, characterization and biochemical properties of the enzyme”. Biochem. J. 326: 683-692. PMID 9307017.
- ↑ Nidetzky, B., Bruggler, K., Kratzer, R. and Mayr, P. (2003). „Multiple forms of xylose reductase in Candida intermedia: comparison of their functional properties using quantitative structure-activity relationships, steady-state kinetic analysis, and pH studies”. J. Agric. Food Chem. 51: 7930-7935. PMID 14690376.
- ↑ Iablochkova, E.N., Bolotnikova, O.I., Mikhailova, N.P., Nemova, N.N. and Ginak, A.I. (2003). „The activity of xylose reductase and xylitol dehydrogenase in yeasts”. Mikrobiologiia 72: 466-469. PMID 14526534.
- ↑ Chen, L.C., Huang, S.C., Chuankhayan, P., Chen, C.D., Huang, Y.C., Jeyakanthan, J., Pang, H.F., Men, L.C., Chen, Y.C., Wang, Y.K., Liu, M.Y., Wu, T.K. and Chen, C.J. (2009). „Purification, crystallization and preliminary X-ray crystallographic analysis of xylose reductase from Candida tropicalis”. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 65: 419-421. PMID 19342796.
- ↑ Verduyn, C., Van Kleef, R., Frank, J., Schreuder, H., Van Dijken, J.P. and Scheffers, W.A. (1985). „Properties of the NAD(P)H-dependent xylose reductase from the xylose-fermenting yeast Pichia stipitis”. Biochem. J. 226: 669-677. PMID 3921014.
- ↑ Fernandes, S., Tuohy, M.G. and Murray, P.G. (2009). „Xylose reductase from the thermophilic fungus Talaromyces emersonii: cloning and heterologous expression of the native gene (Texr) and a double mutant (TexrK271R + N273D) with altered coenzyme specificity”. J. Biosci. 34: 881-890. PMID 20093741.
- ↑ Lee, J.K., Koo, B.S. and Kim, S.Y. (2003). „Cloning and characterization of the xyl1 gene, encoding an NADH-preferring xylose reductase from Candida parapsilosis, and its functional expression in Candida tropicalis”. Appl. Environ. Microbiol. 69: 6179-6188. PMID 14532079.
- ↑ Woodyer, R., Simurdiak, M., van der Donk, W.A. and Zhao, H. (2005). „Heterologous expression, purification, and characterization of a highly active xylose reductase from Neurospora crassa”. Appl. Environ. Microbiol. 71: 1642-1647. PMID 15746370.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.