D-alanin-poli(fosforibitol) ligaza
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| D-alanin-poli(fosforibitol) ligaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 6.1.1.13 | ||||||||
| CAS broj | 9023-65-8 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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D-alanin-poli(fosforibitol) ligaza (EC 6.1.1.13, D-alanil-poli(fosforibitol) sintetaza, D-alanin: membransko akceptorska ligaza, D-alanin-D-alanil nosilac proteinska ligaza, D-alanin-membranska akceptorska ligaza, D-alanin-aktivirajući enzim) je enzim sa sistematskim imenom D-alanin:poli(fosforibitol) ligaza (formira AMP).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
Tioestarska veza se formira tranzijentno između D-alanina i sulfhidrilne grupe 4'-fosfopanteteinske prostetičke grupe D-alanil proteinskog nosioca tokom aktivacije [[alanin]a.
Reference[uredi | uredi kod]
- ↑ Baddiley, J. and Neuhaus, F.C. (1960). „The enzymic activation of D-alanine”. Biochem. J. 75: 579-579. PMID 13795638.
- ↑ Reusch, V.M. and Neuhaus, F.C. (1971). „D-Alanine:membrane acceptor ligase from Lactobacillus casei”. J. Biol. Chem. 246: 6136-6143. PMID 4399593.
- ↑ Perego, M., Glaser, P., Minutello, A., Strauch, M.A., Leopold, K. and Fischer, W. (1995). „Incorporation of D-alanine into lipoteichoic acid and wall teichoic acid in Bacillus subtilis”. J. Biol. Chem. 270: 15598-15606. PMID 7797557.
- ↑ Heaton, M.P. and Neuhaus, F.C. (1994). „Role of D-alanyl carrier protein in the biosynthesis of D-alanyl-lipoteichoic acid”. J. Bacteriol. 176: 681-690. PMID 8300523.
- ↑ Debabov, D.V., Heaton, M.P., Zhang, Q., Stewart, K.D., Lambalot, R.H. and Neuhaus, F.C. (1996). „The D-alanyl carrier protein in Lactobacillus casei: cloning, sequencing and expression of dltC”. J. Bacteriol. 178: 3869-3876. PMID 8682792.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.