D-alanin—D-serin ligaza
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| D-alanin—D-serin ligaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 6.3.2.35 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
D-alanin—D-serin ligaza (EC 6.3.2.35, VanC, VanE, VanG) je enzim sa sistematskim imenom D-alanin:D-serin ligaza (formira ADP).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
Produkt ovog enzima, D-alanil-D-serin, može da bude inkorporiran u peptidoglikanski pentapeptid umesto uobičajenog D-alanil-D-alanin dipeptida.
Reference[uredi | uredi kod]
- ↑ Dutka-Malen, S., Molinas, C., Arthur, M. and Courvalin, P. (1992). „Sequence of the vanC gene of Enterococcus gallinarum BM4174 encoding a D-alanine:D-alanine ligase-related protein necessary for vancomycin resistance”. Gene 112: 53-58. PMID 1551598.
- ↑ Park, I.S., Lin, C.H. and Walsh, C.T. (1997). „Bacterial resistance to vancomycin: overproduction, purification, and characterization of VanC2 from Enterococcus casseliflavus as a D-Ala-D-Ser ligase”. Proc. Natl. Acad. Sci. USA 94: 10040-10044. PMID 9294159.
- ↑ Fines, M., Perichon, B., Reynolds, P., Sahm, D.F. and Courvalin, P. (1999). „VanE, a new type of acquired glycopeptide resistance in Enterococcus faecalis BM4405”. Antimicrob. Agents Chemother. 43: 2161-2164. PMID 10471558.
- ↑ Depardieu, F., Bonora, M.G., Reynolds, P.E. and Courvalin, P. (2003). „The vanG glycopeptide resistance operon from Enterococcus faecalis revisited”. Mol. Microbiol. 50: 931-948. PMID 14617152.
- ↑ Watanabe, S., Kobayashi, N., Quinones, D., Hayakawa, S., Nagashima, S., Uehara, N. and Watanabe, N. (2009). „Genetic diversity of the low-level vancomycin resistance gene vanC-2/vanC-3 and identification of a novel vanC subtype (vanC-4) in Enterococcus casseliflavus”. Microb. Drug Resist. 15: 1-9. PMID 19216682.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.