Cistationinska b-sintaza
(Preusmjereno sa stranice Cistationin beta sintetaza)
| Cistationinska b-sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| |||||||||
| Cistationinska b-sintaza dimer, Human | |||||||||
| Identifikatori | |||||||||
| EC broj | 4.2.1.22 | ||||||||
| CAS broj | 9023-99-8 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Cistationinska b-sintaza (EC 4.2.1.22, serinska sulfhidraza, beta-tionaza, metilcisteinska sintaza, cisteinska sintaza, serin sulfhidrilaza, L-serinska hidrolijaza (dodaje homocistein)) je enzim sa sistematskim imenom L-serin hidrolijaza (dodaje homocistein; formira L-cistationin).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- L-serin + L-homocistein L-cistationin + H2O
Ovaj enzim je piridoksal-fosfatni protein.
Reference[uredi | uredi kod]
- ↑ Braunstein, A.E., Goryachinkova, E.V., Tolosa, E.A., Willhardt, I.H. and Yefremova, L.L. (1971). „Specificity and some other properties of liver serine sulphhydrase: evidence for its identity with cystathionine-synthase”. Biochim. Biophys. Acta, 242: 247-260. PMID 5121611.
- ↑ Nakagawa, H. and Kimura, H. (1968). „Purification and properties of cystathionine synthetase synthetase from rat liver: separation of cystathionine synthetase from serine dehydratase”. Biochem. Biophys. Res. Commun. 32: 209-214. PMID 5672136.
- ↑ Schlossmann, K., Brüggemann, J. and Lynen, F. (1962). „Biosynthese des Cysteins. I. Nachweis und Isolierung der Serinsulfhydrase aus Bäckerhefe”. Biochem. Z. 336: 258-273. PMID 13991884.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.