Ciprofloksacin
(IUPAC ) ime
1-ciklopropil-6-fluoro-4-okso-7-(piperazin-1-il)-hinolin-3-karboksilna kiselina
Klinički podaci
Robne marke
Ciloxan, Cipro, Neofloxin
AHFS/Drugs.com
Monografija
MedlinePlus
a688016
Identifikatori
CAS broj
85721-33-1
ATC kod
J01 MA02 S01 AE03 S02 AA15 S03 AA07
PubChem [1] [2] 2764
DrugBank
DB00537
ChemSpider [3] 2662
UNII
5E8K9I0O4U Y
KEGG [4] D00186 Y
ChEBI
CHEBI:100241 Y
ChEMBL [5] CHEMBL8 Y
Hemijski podaci
Formula
C 17 H 18 F N 3 O 3
Mol. masa
331,346
SMILES
eMolekuli PubHem
InChI InChI=1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24) Y Y
Farmakokinetički podaci
Bioraspoloživost
69%[6]
Metabolizam
Hepatički, uključujući CYP1A2
Poluvreme eliminacije
4 sata
Izlučivanje
Renal
Farmakoinformacioni podaci
Licenca
US FDA :link
Trudnoća
B3(AU ) C(US )
Pravni status
Samo na recept (S4) (AU ) POM (UK ) ℞ -only (SAD )
Način primene
Oralno , intravenozno , topikalno
Ciprofloksacin (INN ) pripada drugoj generaciji fluorohinolonskih antibiotika .[7] [8] Gram-negativne (Escherichia coli Haemophilus influenzae Klebsiella pneumoniae Legionella pneumophila Moraxella catarrhalis Proteus mirabilis Pseudomonas aeruginosa Gram-positivne (meticilin-senzitivni ali ne meticilin-rezistentni Staphylococcus aureus Streptococcus pneumoniae Staphylococcus epidermidis Enterococcus faecalis Streptococcus pyogenes [9]
↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.” . Drug Discov Today 15 (23-24): 1052-7. DOI :10.1016/j.drudis.2010.10.003 . PMID 20970519 . edit ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4 : 217-241. DOI :10.1016/S1574-1400(08)00012-1 . ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining” . J Cheminform 2 (1): 3. DOI :10.1186/1758-2946-2-3 . PMID 20331846 . edit ↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG” . Yeast 17 (1): 48–55. DOI :10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H . ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI :10.1093/nar/gkr777 . PMID 21948594 . edit ↑ Drusano GL, Standiford HC, Plaisance K, Forrest A, Leslie J, Caldwell J (September 1986). „Absolute oral bioavailability of ciprofloxacin” . Antimicrob Agents Chemother. 30 (3): 444–6. ISSN 0066-4804 . PMC 180577 . PMID 3777908 . ↑ Nelson, JM.; Chiller, TM.; Powers, JH.; Angulo, FJ. (Apr 2007). „Fluoroquinolone-resistant Campylobacter species and the withdrawal of fluoroquinolones from use in poultry: a public health success story.”. Clin Infect Dis 44 (7): 977–80. DOI :10.1086/512369 . PMID 17342653 . ↑ Kawahara, S. (Dec 1998). „[Chemotherapeutic agents under study]”. Nippon Rinsho 56 (12): 3096–9. PMID 9883617 . ↑ Brunton, Laurence; Lazo, John; Parker, Keith (2005). Goodman & Gilman's The Pharmacological Basis of Therapeutics ISBN 978-0-07-142280-2 . Pristupljeno 30. 10. 2012 .
