Ciklična piranopterin monofosfatna sintaza

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Ciklična piranopterin monofosfatna sintaza
Identifikatori
EC broj 4.1.99.18
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Ciklična piranopterin monofosfatna sintaza (EC 4.1.99.18, MOCS1A, MoaA, MoaC, molibdenum kofaktor biosinteza protein 1) je enzim sa sistematskim imenom GTP 8,9-lijaza (formira ciklična piranopterin monofosfat).[1][2][3][4][5][6][7] Ovaj enzim katalizuje sledeću hemijsku reakciju

GTP \rightleftharpoons ciklični piranopterin monofosfat + difosfat

Ovaj enzim katalizuje jedan od ranih kraka biosinteze molibdenum kofaktora (MoCo).

Reference[uredi - уреди]

  1. Rieder, C., Eisenreich, W., O'Brien, J., Richter, G., Götze, E., Boyle, P., Blanchard, S., Bacher, A. and Simon, H. (1998). "Rearrangement reactions in the biosynthesis of molybdopterin - an NMR study with multiply 13C/15N labelled precursors". Eur. J. Biochem. 255: 24–36. PMID 9692897. 
  2. Wuebbens, M.M. and Rajagopalan, K.V. (1995). "Investigation of the early steps of molybdopterin biosynthesis in Escherichia coli through the use of in vivo labeling studies". J. Biol. Chem. 270: 1082–1087. PMID 7836363. 
  3. Hänzelmann, P., Hernandez, H.L., Menzel, C., Garcia-Serres, R., Huynh, B.H., Johnson, M.K., Mendel, R.R. and Schindelin, H. (2004). "Characterization of MOCS1A, an oxygen-sensitive iron-sulfur protein involved in human molybdenum cofactor biosynthesis". J. Biol. Chem. 279: 34721–34732. PMID 15180982. 
  4. Hänzelmann, P. and Schindelin, H. (2004). "Crystal structure of the S-adenosylmethionine-dependent enzyme MoaA and its implications for molybdenum cofactor deficiency in humans". Proc. Natl. Acad. Sci. USA 101: 12870–12875. PMID 15317939. 
  5. Sanishvili, R., Beasley, S., Skarina, T., Glesne, D., Joachimiak, A., Edwards, A. and Savchenko, A. (2004). "The crystal structure of Escherichia coli MoaB suggests a probable role in molybdenum cofactor synthesis". J. Biol. Chem. 279: 42139–42146. PMID 15269205. 
  6. Hänzelmann, P. and Schindelin, H. (2006). "Binding of 5′-GTP to the C-terminal FeS cluster of the radical S-adenosylmethionine enzyme MoaA provides insights into its mechanism". Proc. Natl. Acad. Sci. USA 103: 6829–6834. PMID 16632608. 
  7. Lees, N.S., Hänzelmann, P., Hernandez, H.L., Subramanian, S., Schindelin, H., Johnson, M.K. and Hoffman, B.M. (2009). "ENDOR spectroscopy shows that guanine N1 binds to [4Fe-4S] cluster II of the S-adenosylmethionine-dependent enzyme MoaA: mechanistic implications". J. Am. Chem. Soc. 131: 9184–9185. PMID 19566093. 

Literatura[uredi - уреди]

Spoljašnje veze[uredi - уреди]