Glukuronoziltransferaza
| Glukuronoziltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| |||||||||
| Glukuronoziltransferaza monomer, Xanthomonas campestris | |||||||||
| Identifikatori | |||||||||
| EC broj | 2.4.1.17 | ||||||||
| CAS broj | 2604396 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Glukuronoziltransferaza (EC 2.4.1.17, 1-naftol glukuroniltransferaza, 1-naftol-UDP-glukuronaziltransferaza, 17beta-hidroksisteroid UDP-glukuronaziltransferaza, 3alfa-hidroksisteroid UDP-glukuronaziltransferaza, 4-hidroksibifenil UDP-glukuronaziltransferaza, 4-metilumbelliferon UDP-glukuronaziltransferaza, 4-nitrofenol UDP-glukuroniltransferaza, 4-nitrofenol UDPGT, 17-OH steroid UDPGT, 3-OH androgenic UDPGT, bilirubin uridin difosfoglukuroniltransferaza, bilirubin UDP-glukuronaziltransferaza, bilirubin monoglukuronid glukuroniltransferaza, bilirubin UDPGT, bilirubin glukuroniltransferaza, ciramadol UDP-glukuroniltransferaza, estriol UDP-glukuronaziltransferaza, estron UDP-glukuronaziltransferaza, uridin difosfoglukuronaziltransferaza, uridin difosfoglukuronat-bilirubin glukuronazid glukuronaziltransferaza, uridin difosfoglukuronat-bilirubin glukuronaziltransferaza, uridin difosfoglukuronat-estriol glukuronaziltransferaza, uridin difosfoglukuronat-estradiol glukuronaziltransferaza, uridin difosfoglukuronat-4-hidroksibifenil glukuronaziltransferaza, uridin difosfoglukuronat-1,2-diacilglicerol glukuronaziltransferaza, uridin difosfoglukuronat-estriol 16alfa-glukuronaziltransferaza, GT, morfin glukuroniltransferaza, p-hidroksibifenil UDP glukuroniltransferaza, p-nitrofenol UDP-glukuronaziltransferaza, p-nitrofenol UDP-glukuroniltransferaza, p-nitrofenilglukuronaziltransferaza, p-fenilfenol glukuroniltransferaza, fenil-UDP-glukuronaziltransferaza, PNP-UDPGT, UDP glukuronat-estradiol-glukuronaziltransferaza, UDP glukuronaziltransferaza, UDP glukuronat-estriol glukuronaziltransferaza, UDP glukuronska kiselina transferaza, UDP glukuroniltransferaza, UDP-glukuronat-4-hidroksibifenil glukuronaziltransferaza, UDP-glukuronat-bilirubin glukuroniltransferaza, UDP-glukuronaziltransferaza, UDP-glukuroniltransferaza, UDPGA transferaza, UDPGA-glukuroniltransferaza, UDPGT, uridin difosfoglukuroniltransferaza, uridin difosfat glukuroniltransferaza, uridin 5'-difosfoglukuroniltransferaza) je enzim sa sistematskim imenom UDP-glukuronat beta-D-glukuronasiltransferaza (nespecifična za akceptor).[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
- UDP-glukuronat + akceptor UDP + akceptor beta-D-glukuronazid
Ova familija enzima prihvata širok opseg supstrata, uključujući fenole, alkohole, amine i masne kiseline.
Reference[uredi | uredi kod]
- ↑ Bock, K.W., Burchell, B., Dutton, G.J., Hanninen, O., Mulder, G.J., Owens, I.S., Siest, G. and Jephly, T.R. (1983). „UDP-glucuronosyltransferase activities. Guidelines for consistent interim terminology and assay conditions”. Biochem. Pharmacol. 32: 953-955. PMID 6404284.
- ↑ Bock, K.W., Josting, D., Lilienblum, W. and Pfeil, H. (1979). „Purification of rat-liver microsomal UDP-glucuronyltransferase. Separation of two enzyme forms inducible by 3-methylcholanthrene or phenobarbital”. Eur. J. Biochem. 98: 19-26. PMID 111930.
- ↑ Burchell, B. (1981). „Identification and purification of multiple forms of UDP-glucuronosyltransferase”. Rev. Biochem. Toxicol. 3: 1-32.
- ↑ Dutton, G.J. (1980). Glucuronidation of Drugs and Other Compounds. Boca Raton, Florida: C.R.C. Press. str. -.
- ↑ Green, M.D., Falany, C.N., Kirkpatrick, R.B. and Tephly, T.R. (1985). „Strain differences in purified rat hepatic 3α-hydroxysteroid UDP-glucuronosyltransferase”. Biochem. J. 230: 403-409. PMID 3931633.
- ↑ Jansen, P.L.M. (1974). „The enzyme-catalyzed formation of bilirubin diglucuronide by a solublized preparation from cat liver microsomes”. Biochim. Biophys. Acta 338: 170-182.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
- Dutton, G.J. (1980). Glucuronidation of Drugs and Other Compounds. Boca Raton, Florida: C.R.C. Press. str. -.