Beta-ketoacil-(acil-nosilac-protein) sintaza II

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Beta-ketoacil-(acil-nosilac-protein) sintaza II
Identifikatori
EC broj 2.3.1.179
CAS broj 1048648-42-5
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Beta-ketoacil-(acil-nosilac-protein) sintaza II (EC 2.3.1.179, KASII, KAS II, FabF, 3-oksoacil-acil nosilac protein sintaza I, beta-ketoacil-ACP sintaza II, (Z)-heksadec-11-enoil-(acil-nosilac-protein):malonil-(acil-nosilac-protein) C-aciltransferaza (dekarboksilacija)) je enzim sa sistematskim imenom (Z)-heksadek-11-enoil-(acil-nosilac protein):malonil-(acil-nosilac protein) C-aciltransferaza (dekarboksilacija).[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju

(Z)-heksadek-11-enoil-[acil-nosilac protein] + malonil-[acil-nosilac protein] \rightleftharpoons (Z)-3-oksooktadek-13-enoil-[acil-nosilac protein] + CO2 + [acil-nosilac protein]

Ovaj enzim učestvuje u sistemu biosinteze disociranih masnih kiselina kod biljki i bakterija.

Reference[uredi - уреди]

  1. D'Agnolo, G., Rosenfeld, I.S. and Vagelos, P.R. (1975). "Multiple forms of β-ketoacyl-acyl carrier protein synthetase in Escherichia coli". J. Biol. Chem. 250: 5289–5294. PMID 237914. 
  2. Garwin, J.L., Klages, A.L. and Cronan, J.E., Jr.. (1980). "Structural, enzymatic, and genetic studies of β-ketoacyl-acyl carrier protein synthases I and II of Escherichia coli". J. Biol. Chem. 255: 11949–11956. PMID 7002930. 
  3. Price, A.C., Rock, C.O. and White, S.W. (2003). "The 1.3-Angstrom-resolution crystal structure of β-ketoacyl-acyl carrier protein synthase II from Streptococcus pneumoniae". J. Bacteriol. 185: 4136–4143. PMID 12837788. 
  4. Garwin, J.L., Klages, A.L. and Cronan, J.E., Jr. (1980). "β-Ketoacyl-acyl carrier protein synthase II of Escherichia coli. Evidence for function in the thermal regulation of fatty acid synthesis". J. Biol. Chem. 255: 3263–3265. PMID 6988423. 
  5. Magnuson, K., Carey, M.R. and Cronan, J.E., Jr. (1995). "The putative fabJ gene of Escherichia coli fatty acid synthesis is the fabF gene". J. Bacteriol. 177: 3593–3595. PMID 7768872. 
  6. Cronan, J.E., Jr. and Rock, C.O. (1996). "Biosynthesis of membrane lipids". u: Neidhardt, F.C.. Escherichia coli and Salmonella: Cellular and Molecular Biology. 1 (2nd izd.). Washington, DC: ASM Press. str. 612-636. 

Literatura[uredi - уреди]

  • Cronan, J.E., Jr. and Rock, C.O. (1996). "Biosynthesis of membrane lipids". u: Neidhardt, F.C.. Escherichia coli and Salmonella: Cellular and Molecular Biology. 1 (2nd izd.). Washington, DC: ASM Press. str. 612-636. 

Vanjske veze[uredi - уреди]