Beta-amirinska sintaza

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Beta-amirinska sintaza
Identifikatori
EC broj 5.4.99.39
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Beta-amirinska sintaza (EC 5.4.99.39, 2,3-oksidoskvalen beta-amirin ciklaza, AsbAS1, BPY, EtAS, GgbAS1, LjAMY1, MtAMY1, PNY, BgbAS) je enzim sa sistematskim imenom (3S)-2,3-epoksi-2,3-dihidroskvalen mutaza (ciklizacija, formira beta-amirin).[1][2][3][4][5][6][7][8][9][10][11] Ovaj enzim katalizuje sledeću hemijsku reakciju

(3S)-2,3-epoksi-2,3-dihidroskvalen \rightleftharpoons beta-amirin

Neki organizmi poseduju monofunkcionalnu beta-amirinsku sintazu.

Reference[uredi - уреди]

  1. Abe, I, Ebizuka, Y., Seo, S. and Sankawa, U. (1989). "Purification of squalene-2,3-epoxide cyclases from cell suspension cultures of Rabdosia japonica' Hara". FEBS Lett. 249: 100–104. 
  2. Abe, I., Sankawa, U. and Ebizuka, Y. (1989). "Purification of 2,3-oxdosqualene:β-amyrin cyclase from pea seedlings". Chem. Pharm. Bull. 37: 536–. 
  3. Kushiro, T., Shibuya, M. and Ebizuka, Y. (1998). "β-Amyrin synthase-cloning of oxidosqualene cyclase that catalyzes the formation of the most popular triterpene among higher plants". Eur. J. Biochem. 256: 238–244. PMID 9746369. 
  4. Hayashi, H., Huang, P., Kirakosyan, A., Inoue, K., Hiraoka, N., Ikeshiro, Y., Kushiro, T., Shibuya, M. and Ebizuka, Y. (2001). "Cloning and characterization of a cDNA encoding β-amyrin synthase involved in glycyrrhizin and soyasaponin biosyntheses in licorice". Biol. Pharm. Bull. 24: 912–916. PMID 11510484. 
  5. Husselstein-Muller, T., Schaller, H. and Benveniste, P. (2001). "Molecular cloning and expression in yeast of 2,3-oxidosqualene-triterpenoid cyclases from Arabidopsis thaliana". Plant Mol. Biol. 45: 75–92. PMID 11247608. 
  6. Iturbe-Ormaetxe, I., Haralampidis, K., Papadopoulou, K. and Osbourn, A.E. (2003). "Molecular cloning and characterization of triterpene synthases from Medicago truncatula and Lotus japonicus". Plant Mol. Biol. 51: 731–743. PMID 12683345. 
  7. Zhang, H., Shibuya, M., Yokota, S. and Ebizuka, Y. (2003). "Oxidosqualene cyclases from cell suspension cultures of Betula platyphylla var. japonica: molecular evolution of oxidosqualene cyclases in higher plants". Biol. Pharm. Bull. 26: 642–650. PMID 12736505. 
  8. Hayashi, H., Huang, P., Takada, S., Obinata, M., Inoue, K., Shibuya, M. and Ebizuka, Y. (2004). "Differential expression of three oxidosqualene cyclase mRNAs in Glycyrrhiza glabra". Biol. Pharm. Bull. 27: 1086–1092. PMID 15256745. 
  9. Kajikawa, M., Yamato, K.T., Fukuzawa, H., Sakai, Y., Uchida, H. and Ohyama, K. (2005). "Cloning and characterization of a cDNA encoding β-amyrin synthase from petroleum plant Euphorbia tirucalli L". Phytochemistry 66: 1759–1766. PMID 16005035. 
  10. Basyuni, M., Oku, H., Tsujimoto, E., Kinjo, K., Baba, S. and Takara, K. (2007). "Triterpene synthases from the Okinawan mangrove tribe, Rhizophoraceae". FEBS J. 274: 5028–5042. PMID 17803686. 
  11. Liu, Y., Cai, Y., Zhao, Z., Wang, J., Li, J., Xin, W., Xia, G. and Xiang, F. (2009). "Cloning and functional analysis of a β-amyrin synthase gene associated with oleanolic acid biosynthesis in Gentiana straminea MAXIM". Biol. Pharm. Bull. 32: 818–824. PMID 19420748. 

Literatura[uredi - уреди]

Vanjske veze[uredi - уреди]