Bajikalin-beta-D-glukuronidaza
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| Baikalin-beta-D-glukuronidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.2.1.167 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Baikalin-beta-D-glukuronidaza (EC 3.2.1.167, bajikalinaza) je enzim sa sistematskim imenom 5,6,7-trihidroksiflavon-7-O-beta-D-glukupiranoziduronatna glukuronazilhidrolaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- bajikalin + H2O bajikalein + D-glukuronat
Ovaj enzim takođe u manjoj meri hidrolizuje vogonin 7-O-beta-D-glukuronid i oroksilin 7-O-beta-D-glukuronid.
Reference[uredi | uredi kod]
- ↑ Ikegami, F., Matsunae, K., Hisamitsu, M., Kurihara, T., Yamamoto, T. and Murakoshi, I. (1995). „Purification and properties of a plant β-D-glucuronidase form Scutellaria root”. Biol. Pharm. Bull. 18: 1531-1534. PMID 8593473.
- ↑ Zhang, C., Zhang, Y., Chen, J. and Liang, X. (2005). „Purification and characterization of baicalin-β-D-glucuronidase hydrolyzing baicalin to baicalein from fresh roots of Scutellaria viscidula Bge”. Proc. Biochem. 40: 1911-1915.
- ↑ Sasaki, K., Taura, F., Shoyama, Y. and Morimoto, S. (2000). „Molecular characterization of a novel β-glucuronidase from Scutellaria baicalensis Georgi”. J. Biol. Chem. 275: 27466-27472. PMID 10858442.
- ↑ Morimoto, S., Harioka, T. and Shoyama, Y. (1995). „Purification and characterization of flavone-specific β-glucuronidase from callus cultures of Scutellaria baicalensis Georgi”. Planta 195: 535-540.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.