BD-1063
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| |||
| (IUPAC) ime | |||
|---|---|---|---|
| 1-[2-(3,4-dichlorophenyl)ethyl]-4-methylpiperazine | |||
| Klinički podaci | |||
| Identifikatori | |||
| CAS broj | 150208-28-9 | ||
| ATC kod | nije dodeljen | ||
| PubChem[1][2] | 574780 | ||
| Hemijski podaci | |||
| Formula | C13H18Cl2N2 | ||
| Mol. masa | 273.201 g/mol | ||
| SMILES | eMolekuli & PubHem | ||
| |||
| Farmakoinformacioni podaci | |||
| Trudnoća | ? | ||
| Pravni status | |||
BD-1063 je antagonist sigma receptora koji je selektivan za σ1 tip. On blokira MDMA efekte u studijama na životinjama,[3] i umanjuje unos alkohola u modelima alkoholizma.[4]
Literatura[uredi | uredi kod]
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Brammer MK, Gilmore DL, Matsumoto RR (December 2006). „Interactions between 3,4-methylenedioxymethamphetamine and sigma1 receptors”. European Journal of Pharmacology 553 (1-3): 141–5. DOI:10.1016/j.ejphar.2006.09.038. PMC 1780037. PMID 17070798.
- ↑ Sabino V, Cottone P, Zhao Y, Iyer MR, Steardo L, Steardo L, Rice KC, Conti B, Koob GF, Zorrilla EP (May 2009). „The sigma-receptor antagonist BD-1063 decreases ethanol intake and reinforcement in animal models of excessive drinking”. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology 34 (6): 1482–93. DOI:10.1038/npp.2008.192. PMC 2669694. PMID 18946467.
