B-galaktozid a-2,6-sijaliltransferaza

Izvor: Wikipedia
B-galaktozid a-2,6-sijaliltransferaza
Identifikatori
EC broj 2.4.99.1
CAS broj 9075-81-4
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

B-galaktozid a-2,6-sijaliltransferaza (EC 2.4.99.1, CMP-N-acetilneuraminat:beta-D-galaktozil-1,4-N-acetil-beta-D-glukozamin alfa-2,6-N-acetilneuraminiltransferaza) je enzim sa sistematskim imenom CMP-N-acetilneuraminat:beta-D-galaktozil-(1->4)-N-acetil-beta-D-glukozamin alfa-(2->6)-N-acetilneuraminiltransferaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju

CMP-N-acetilneuraminat + beta-D-galaktozil-(1->4)-N-acetil-beta-D-glukozamin \rightleftharpoons CMP + alfa-N-acetilneuraminil-(2->6)-beta-D-galaktozil-(1->4)-N-acetil-beta-D-glukozamin

Terminalni beta-D-galaktozilni ostatak oligosaharida glikoproteina, kao i laktoza, mogu da deluju kao akceptori.

Reference[uredi - уреди]

  1. Bartholomew, B.A., Jourdian, G.W. and Roseman, S. (1973). "The sialic acids. XV. Transfer of sialic acid to glycoproteins by a sialyltransferase from colostrum". J. Biol. Chem. 248: 5751–5762. PMID 4723915. 
  2. Hickman, J., Ashwell, G., Morell, A.G., van der Hamer, C.J.A. and Scheinberg, I.H. (1970). "Physical and chemical studies on ceruloplasmin. 8. Preparation of N-acetylneuraminic acid-1-14C-labeled ceruloplasmin". J. Biol. Chem. 245: 759–766. PMID 4313609. 
  3. Paulson, J.C., Beranek, W.E. and Hill, R.L. (1977). "Purification of a sialyltransferase from bovine colostrum by affinity chromatography on CDP-agarose". J. Biol. Chem. 252: 2356–2362. PMID 849932. 
  4. Schachter, H., Narasimhan, S., Gleeson, P. and Vella, G. (1983). "Glycosyltransferases involved in elongation of N-glycosidically linked oligosaccharides of the complex or N-acetyllactosamine type". Methods Enzymol. 98: 98–134. PMID 6366476. 
  5. Spiro, M.H. and Spiro, R.G. (1968). "Glycoprotein biosynthesis: studies on thyroglobulin. Thyroid sialyltransferase". J. Biol. Chem. 243: 6520–6528. PMID 5726897. 

Literatura[uredi - уреди]

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