Alminoprofen
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| |||
| (IUPAC) ime | |||
|---|---|---|---|
| 2-[4-(2-methylprop-2-enylamino)phenyl]propanoic acid | |||
| Klinički podaci | |||
| AHFS/Drugs.com | Internacionalno ime leka | ||
| Identifikatori | |||
| CAS broj | 39718-89-3 | ||
| ATC kod | M01AE16 | ||
| PubChem[1][2] | 2097 | ||
| ChemSpider[3] | 2013 | ||
| UNII | 0255AHR9GJ 
| ||
| KEGG[4] | D01513
| ||
| Hemijski podaci | |||
| Formula | C13H17NO2 | ||
| Mol. masa | 219.27958 g/mol | ||
| SMILES | eMolekuli & PubHem | ||
| |||
| Farmakoinformacioni podaci | |||
| Trudnoća | ? | ||
| Pravni status | |||
Alminoprofen ke nesteroidni antiinflamatorni lek iz klase fenilpropionskih kiselina.[5][6] Njegove antiinflamatorne osobine se razlikuju od klasičnih NSAID lekova.
Mehanizam dejstva[uredi | uredi kod]
In vitro ispitivanja i in vivo modeli su pokazali da su inflamatorna svojstva alminoprofena posledica njegovog delovanja na fosfolipazu A2 (PLA2) i cikloksigenazu (COX-2).[7]
Reference[uredi | uredi kod]
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.
- ↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
- ↑ B. Dumaitre et al. (1979). „Synthesis, pharmacology and toxicity data,”. Eur. J. Med. Chem. 14: 207.
- ↑ A. Premel-Cabic et al. (1980). „Pharmacokinetic study”. Eur. J. Clin. Pharmacol. 18: 419.
- ↑ Raguenes-Nicol C, Russo-Marie F, Domage G, Diab N, Solito E, Dray F, Mace JL, Streichenberger G. (1999). „Anti-inflammatory mechanism of alminoprofen: action on the phospholipid metabolism pathway”. Biochem Pharmacol 4: 433-43.