Akonitaza
Prijeđi na navigaciju
Prijeđi na pretragu
| Akonitat hidrataza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| |||||||||
| Ilustracija akonitaze svinje u kompleksu sa [Fe4S4] klusterom.[1] | |||||||||
| Identifikatori | |||||||||
| EC broj | 4.2.1.3 | ||||||||
| CAS broj | 9024-25-3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| Ontologija gena | AmiGO / EGO | ||||||||
| |||||||||
Akonitaza je trivijalni naziv za gvožđe-sumporni enzim akonitat hidratazu (citrat hidrolijazu, EC 4.2.1.3) koji katalizuje reverzibilne reakcije stereospecifične izomerizacije citrata, cis-akonitata i izocitrata u Krebsovom ciklusu.[2][3][4]
Reference[uredi | uredi kod]
- ↑ PDB 7ACN; Lauble, H.; Kennedy, M. C.; Beinert, H.; Stout, C. D. (1992). „Crystal structures of aconitase with isocitrate and nitroisocitrate bound”. Biochemistry 31 (10): 2735–48. DOI:10.1021/bi00125a014. PMID 1547214.
- ↑ Beinert, H; Kennedy, MC (1993). „Aconitase, a two-faced protein: Enzyme and iron regulatory factor”. The FASEB Journal 7 (15): 1442–9. PMID 8262329.
- ↑ Flint, Dennis H.; Allen, Ronda M. (1996). „Iron−Sulfur Proteins with Nonredox Functions”. Chemical Reviews 96 (7): 2315–34. DOI:10.1021/cr950041r.
- ↑ Beinert, Helmut; Kennedy, Mary Claire; Stout, C. David (1996). „Aconitase as Iron−Sulfur Protein, Enzyme, and Iron-Regulatory Protein”. Chemical Reviews 96 (7): 2335–74. DOI:10.1021/cr950040z. PMID 11848830.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
