Adenozil-fluorid sintaza
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| Adenozil-fluorid sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| |||||||||
| Heksamer fluorinaze | |||||||||
| Identifikatori | |||||||||
| EC broj | 2.5.1.63 | ||||||||
| CAS broj | 438583-16-5 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Adenozil-fluorid sintaza (EC 2.5.1.63, fluorinaza) je enzim sa sistematskim imenom S-adenozil-L-metionin:fluorid adenoziltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- S-adenozil-L-metionin + fluorid 5'-dezoksi-5'-fluoroadenozin + L-metionin
Reference[uredi | uredi kod]
- ↑ O'Hagan, D., Schaffrath, C., Cobb, S.L., Hamilton, J.T. and Murphy, C.D. (2002). „Biosynthesis of an organofluorine molecule”. Nature 416: 279-279. PMID 11907567.
- ↑ Dong, C., Huang, F., Deng, H., Schaffrath, C., Specner, J.B., O'Hagan, D. and Naismith, J.H. (2004). „Crystal structure and mechanism of a bacterial fluorinating enzyme”. Nature 427: 561-565. PMID 14765200.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.