Acil-homoserin-laktonska acilaza
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| Acil-homoserin-laktonska acilaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.5.1.97 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Acil-homoserin-laktonska acilaza (EC 3.5.1.97, acil-homoserin laktonska acilaza, AHL-acilaza, AiiD, N-acil-homoserin laktonska acilaza, PA2385 protein, PvdQ, QuiP) je enzim sa sistematskim imenom N-acil-L-homoserin-lakton amidohidrolaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- N-acil-L-homoserin lakton + H2O L-homoserin lakton + karboksilat
Acil-homoserinske laktone (AHL) formiraju brojne bakterijske vrste.
Reference[uredi | uredi kod]
- ↑ Sio, C.F., Otten, L.G., Cool, R.H., Diggle, S.P., Braun, P.G., Bos, R., Daykin, M., Cámara, M., Williams, P. and Quax, W.J. (2006). „Quorum quenching by an N-acyl-homoserine lactone acylase from Pseudomonas aeruginosa PAO1”. Infect. Immun. 74: 1673-1682. PMID 16495538.
- ↑ Lin, Y.H., Xu, J.L., Hu, J., Wang, L.H., Ong, S.L., Leadbetter, J.R. and Zhang, L.H. (2003). „Acyl-homoserine lactone acylase from Ralstonia strain XJ12B represents a novel and potent class of quorum-quenching enzymes”. Mol. Microbiol. 47: 849-860. PMID 12535081.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.