8-Ciklopentil-1,3-dimetilksantin

Izvor: Wikipedia
8-Ciklopentil-1,3-dimetilksantin
(IUPAC) ime
8-ciklopentil-1,3-dimetil-7H-purin-2,6-dion
Klinički podaci
Identifikatori
CAS broj 35873-49-5
ATC kod nije dodeljen
PubChem[1][2] 1917
ChemSpider[3] 1843
ChEMBL[4] CHEMBL106265 YesY
Hemijski podaci
Formula C12H16N4O2 
Mol. masa 248,280 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća  ?
Pravni status Nije kontrolisan

8-Ciklopentil-1,3-dimetilksantin (8-Ciklopentilteofilin, 8-CPT, CPX) je lek koji deluje kao potentan i selektivan antagonist adenozinskih receptora, sa izvesnom selektivnošću za A1 receptor, kao i neselektivni inhibitor fosfodiesteraze. On ima stimulišuće dejstvo u životinjskim studijama sa malo većom potencijom od kofeina.[5][6]

Reference[uredi - уреди]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. doi:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. doi:10.1186/1758-2946-2-3. PMID 20331846.  edit
  4. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. doi:10.1093/nar/gkr777. PMID 21948594.  edit
  5. Spealman RD (1988). "Psychomotor stimulant effects of methylxanthines in squirrel monkeys: relation to adenosine antagonism". Psychopharmacology 95 (1): 19–24. PMID 3133696. 
  6. Karcz-Kubicha M, Antoniou K, Terasmaa A, Quarta D, Solinas M, Justinova Z, Pezzola A, Reggio R, Müller CE, Fuxe K, Goldberg SR, Popoli P, Ferré S (July 2003). "Involvement of adenosine A1 and A2A receptors in the motor effects of caffeine after its acute and chronic administration". Neuropsychopharmacology 28 (7): 1281–91. doi:10.1038/sj.npp.1300167. PMID 12700682. 

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