6-Metilenedihidrodezoksimorfin

6-Metilenedihidrodezoksimorfin
(IUPAC) ime
	4,5-α-epoksi- 17-metil- 6-metilenemorfinan- 3-ol
Klinički podaci
Identifikatori
CAS broj	3414-84-4
ATC kod	nije dodeljen
PubChem	5492874
ChemSpider	4591200
Hemijski podaci
Formula	C18H21NO2
Mol. masa	283,36 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C18H21NO2/c1-10-3-5-12-13-9-11-4-6-14(20)16-15(11)18(12,17(10)21-16)7-8-19(13)2/h4,6,12-13,17,20H,1,3,5,7-9H2,2H3/t12-,13+,17-,18-/m0/s1 ; Key: LBCZKDPFDXFDTN-GGNLRSJOSA-N
Sinonimi	6-MDDM, 6-Methylene- dihydrodesoxymorphine
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

6-Metilenedihidrodezoksimorfin (6-MDDM) he opijatni analog koji je izveden iz hidromorfona, gde je 6-ketonska grupa zamenjena metilenom. On ima sedativne i analgetičke efekte.

6-Metilenedihidrodezoksimorfin je potentan agonist μ-opioidnog receptora, koji je 80x jači od morfina.^[4] U poređenju sa morfinom on brže deluje i ima sličnu dužinu trajanja.^[5]

Reference[uredi | uredi kod]

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ „Chemistry of Opioid Analgesics PHA 4220 - Neurology Pharmacotherapeutics.”. Arhivirano iz originala na datum 2007-07-16. Pristupljeno 2014-04-05.
↑ Abdel-Rahman MA, Elliott HW, Binks R, Küng W, Rapoport H. Synthesis and Pharmacology of 6-Methylenedihydrodesoxymorphine. Journal of Medicinal Chemistry. 1966; 9(1):1-6.

Vidi još[uredi | uredi kod]

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] „Chemistry of Opioid Analgesics PHA 4220 - Neurology Pharmacotherapeutics.”. Arhivirano iz originala na datum 2007-07-16. Pristupljeno 2014-04-05.

[5] Abdel-Rahman MA, Elliott HW, Binks R, Küng W, Rapoport H. Synthesis and Pharmacology of 6-Methylenedihydrodesoxymorphine. Journal of Medicinal Chemistry. 1966; 9(1):1-6.

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6-Metilenedihidrodezoksimorfin

Reference[uredi | uredi kod]

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