5-Epiaristolohenska sintaza
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| 5-Epiaristolohenska sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.3.61 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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5-Epiaristolohenska sintaza (EC 4.2.3.61, 5-epi-aristolohenska sintaza, tobako epiaristolohenska sintaza, farnezil pirofosfatna ciklaza, EAS, TEAS) je enzim sa sistematskim imenom (2E,6E)-farnezil-difosfat difosfat-lijaza (formira (+)-5-epiaristolohen).[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (2E,6E)-farnezil difosfat (+)-5-epiaristolohen + difosfat
Inicijalna ciklizacija daje (+)-germakren A koji je vezan za enzim.
Reference[uredi | uredi kod]
- ↑ Back, K., Yin, S. and Chappell, J. (1994). „Expression of a plant sesquiterpene cyclase gene in Escherichia coli”. Arch. Biochem. Biophys. 315: 527-532. PMID 7986100.
- ↑ Starks, C.M., Back, K., Chappell, J. and Noel, J.P. (1997). „Structural basis for cyclic terpene biosynthesis by tobacco 5-epi-aristolochene synthase”. Science 277: 1815-1820. PMID 9295271.
- ↑ Back, K., He, S., Kim, K.U. and Shin, D.H. (1998). „Cloning and bacterial expression of sesquiterpene cyclase, a key branch point enzyme for the synthesis of sesquiterpenoid phytoalexin capsidiol in UV-challenged leaves of Capsicum annuum”. Plant Cell Physiol. 39: 899-904. PMID 9816674.
- ↑ Rising, K.A., Starks, C.M., Noel, J.P. and Chappell, J. (2000). „Demonstration of germacrene A as an intermediate in 5-epi-aristolochene synthase catalysis”. J. Am. Chem. Soc. 122: 1861-1866.
- ↑ Bohlmann, J., Stauber, E.J., Krock, B., Oldham, N.J., Gershenzon, J. and Baldwin, I.T. (2002). „Gene expression of 5-epi-aristolochene synthase and formation of capsidiol in roots of Nicotiana attenuata and N. sylvestris'”. Phytochemistry 60: 109-116. PMID 12009313.
- ↑ O'Maille, P.E., Chappell, J. and Noel, J.P. (2006). „Biosynthetic potential of sesquiterpene synthases: alternative products of tobacco 5-epi-aristolochene synthase”. Arch. Biochem. Biophys. 448: 73-82. PMID 16375847.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.