3a,7a,12a-trihidroksi-5b-holest-24-enoil-KoA dehidrataza

Izvor: Wikipedia
3a,7a,12a-trihidroksi-5b-holest-24-enoil-KoA dehidrataza
Identifikatori
EC broj 4.2.1.107
CAS broj 152787-68-3
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

3a,7a,12a-trihidroksi-5b-holest-24-enoil-KoA dehidrataza (EC 4.2.1.107, 46 kDa hidrataza 2, (24R,25R)-3alfa,7alfa,12alfa,24-tetrahidroksi-5beta-holestanoil-KoA hidrolijaza) je enzim sa sistematskim imenom (24R,25R)-3alfa,7alfa,12alfa,24-tetrahidroksi-5beta-holestanoil-KoA hidrolijaza (formira (24E)-3alfa,7alfa,12alfa-trihidroksi-5beta-holest-24-enoil-KoA).[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju

(24R,25R)-3alfa,7alfa,12alfa,24-tetrahidroksi-5beta-holestanoil-KoA \rightleftharpoons (24E)-3alfa,7alfa,12alfa-trihidroksi-5beta-holest-24-enoil-KoA + H2O

Ovaj enzim je deo peroksizomalnog multifunktionalnog enzim perMFE-2 kod pacova.

Reference[uredi - уреди]

  1. Qin, Y.M., Haapalainen, A.M., Conry, D., Cuebas, D.A., Hiltunen, J.K. and Novikov, D.K. (1997). "Recombinant 2-enoyl-CoA hydratase derived from rat peroxisomal multifunctional enzyme 2: role of the hydratase reaction in bile acid synthesis". Biochem. J. 328: 377–382. PMID 9371691. 
  2. Xu, R. and Cuebas, D.A. (1996). "The reactions catalyzed by the inducible bifunctional enzyme of rat liver peroxisomes cannot lead to the formation of bile acids". Biochem. Biophys. Res. Commun. 221: 271–278. PMID 8619845. 
  3. Kinoshita, T., Miyata, M., Ismail, S.M., Fujimoto, Y., Kakinuma, K., Kokawa, N.I. and Morisaki, M. (1988). "Synthesis and determination of stereochemistry of four diastereoisomers at the C-24 and C-25 positions of 3α,7α,12α,24-tetrahydroxy-5β-cholestan-26-oic acid and cholic acid". Chem. Pharm. Bull. 36: 134–141. 
  4. Fujimoto, Y., Kinoshita, T., Oya, I., Kakinuma, K., Ismail, S.M., Sonoda, Y., Sato, Y. and Morisaki, M. (1988). "Non-stereoselective conversion of the four diastereoisomers at the C-24 and C-25 positions of 3α,7α,12α,24-tetrahydroxy-5β-cholestan-26-oic acid and cholic acid". Chem. Pharm. Bull. 36: 142–145. 
  5. Kurosawa, T., Sato, M., Nakano, H., Fujiwara, M., Murai, T., Yoshimura, T. and Hashimoto, T. (2001). "Conjugation reactions catalyzed by bifunctional proteins related to β-oxidation in bile acid biosynthesis". Steroids 66: 107–114. PMID 11146090. 
  6. Russell, D.W. (2003). "The enzymes, regulation, and genetics of bile acid synthesis". Annu. Rev. Biochem. 72: 137–174. PMID 12543708. 

Literatura[uredi - уреди]

Spoljašnje veze[uredi - уреди]