3-Oksoacil-(acil-nosilac-protein) sintaza

Izvor: Wikipedia
3-Oksoacil-(acil-nosilac-protein) sintaza
Identifikatori
EC broj 2.3.1.41
CAS broj 2621625
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

3-Oksoacil-(acil-nosilac-protein) sintaza (EC 2.3.1.41, beta-ketoacil-ACP sintaza I, beta-ketoacilna sintetaza, beta-ketoacil-ACP sintetaza, beta-ketoacil-acil nosilac protein sintetaza, beta-ketoacil-(acil nosilac protein) sintaza, beta-ketoacilsintaza, 3-ketoacil-acil nosilac protein sintaza, beta-ketoacil acil nosilac protein sintaza, 3-oksoacil:ACP sintaza I, KASI, KAS I, FabF1, FabB, acil-(acil-nosilac-protein):malonil-(acil-nosilac-protein) C-aciltransferaza (dekarboksilacija)) je enzim sa sistematskim imenom acil-(acil-nosilac protein):malonil-(acil-nosilac protein) C-aciltransferaza (dekarboksilacija).[1][2][3][4][5][6][7] Ovaj enzim katalizuje sledeću hemijsku reakciju

acil-[acil-nosilac protein] + malonil-[acil-nosilac protein] \rightleftharpoons 3-oksoacil-[acil-nosilac protein] + CO2 + [acil-nosilac protein]

Ovaj enzim je odgovoran za produžavanje lanca pri biosintezi disociranih (tip II) masnih kiselina, i.e. adicija dva C atoma na masno kiselinski lanac. Escherichia coli mutanti kojima nedostaje ovaj enzim su deficitarni u nezasićenim masnim kiselinama.

Reference[uredi - уреди]

  1. Alberts, A.W., Majerus, P.W. and Vagelos, P.R. (1969). "Acetyl-CoA acyl carrier protein transacylase". Methods Enzymol. 14: 50–53. 
  2. Prescott, D.J. and Vagelos, P.R. (1972). "Acyl carrier protein". Adv. Enzymol. Relat. Areas Mol. Biol. 36: 269–311. PMID 4561013. 
  3. Toomey, R.E. and Wakil, S.J. (1966). "Studies on the mechanism of fatty acid synthesis. XVI. Preparation and general properties of acyl-malonyl acyl carrier protein-condensing enzyme from Escherichia coli". J. Biol. Chem. 241: 1159–1165. PMID 5327099. 
  4. D'Agnolo, G., Rosenfeld, I.S. and Vagelos, P.R. (1975). "Multiple forms of β-ketoacyl-acyl carrier protein synthetase in Escherichia coli". J. Biol. Chem. 250: 5289–5294. PMID 237914. 
  5. Garwin, J.L., Klages, A.L. and Cronan, J.E., Jr.. (1980). "Structural, enzymatic, and genetic studies of β-ketoacyl-acyl carrier protein synthases I and II of Escherichia coli". J. Biol. Chem. 255: 11949–11956. PMID 7002930. 
  6. Wang, H. and Cronan, J.E. (2004). "Functional replacement of the FabA and FabB proteins of Escherichia coli fatty acid synthesis by Enterococcus faecalis FabZ and FabF homologues". J. Biol. Chem. 279: 34489–34495. PMID 15194690. 
  7. Cronan, J.E., Jr. and Rock, C.O. (1996). "Biosynthesis of membrane lipids". u: Neidhardt, F.C.. Escherichia coli and Salmonella: Cellular and Molecular Biology. 1 (2nd izd.). Washington, DC: ASM Press. str. 612-636. 

Literatura[uredi - уреди]

  • Cronan, J.E., Jr. and Rock, C.O. (1996). "Biosynthesis of membrane lipids". u: Neidhardt, F.C.. Escherichia coli and Salmonella: Cellular and Molecular Biology. 1 (2nd izd.). Washington, DC: ASM Press. str. 612-636. 

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