3',5'-Ciklični-AMP fosfodiestaraza

Izvor: Wikipedia
3',5'-Ciklični-AMP fosfodiestaraza
Identifikatori
EC broj 3.1.4.53
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

3',5'-Ciklični-AMP fosfodiestaraza (EC 3.1.4.53, cAMP-specifična fosfodiesteraza, cAMP-specifična PDE, PDE1, PDE2A, PDE2B, PDE4, PDE7, PDE8, PDEB1, PDEB2) je enzim sa sistematskim imenom 3',5'-ciklična-AMP 5'-nukleotidohidrolaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju

adenozin 3',5'-ciklična fosfat + H2O \rightleftharpoons AMP

Za dejstvo ovog enzim je neophodan jon Mg2+ ili Mn2+.

Reference[uredi - уреди]

  1. Alonso, G.D., Schoijet, A.C., Torres, H.N. and Flawiá, M.M. (2006). "TcPDE4, a novel membrane-associated cAMP-specific phosphodiesterase from Trypanosoma cruzi". Mol. Biochem. Parasitol. 145: 40–49. PMID 16225937. 
  2. Bader, S., Kortholt, A., Snippe, H. and Van Haastert, P.J. (2006). "DdPDE4, a novel cAMP-specific phosphodiesterase at the surface of Dictyostelium cells". J. Biol. Chem. 281: 20018–20026. PMID 16644729. 
  3. Rascón, A., Soderling, S.H., Schaefer, J.B. and Beavo, J.A. (2002). "Cloning and characterization of a cAMP-specific phosphodiesterase (TbPDE2B) from Trypanosoma brucei". Proc. Natl. Acad. Sci. USA 99: 4714–4719. PMID 11930017. 
  4. Johner, A., Kunz, S., Linder, M., Shakur, Y. and Seebeck, T. (2006). "Cyclic nucleotide specific phosphodiesterases of Leishmania major". BMC Microbiol. 6: #25–25. PMID 16522215. 
  5. Lugnier, C., Keravis, T., Le Bec, A., Pauvert, O., Proteau, S. and Rousseau, E. (1999). "Characterization of cyclic nucleotide phosphodiesterase isoforms associated to isolated cardiac nuclei". Biochim. Biophys. Acta 1472: 431–446. PMID 10564757. 
  6. Imamura, R., Yamanaka, K., Ogura, T., Hiraga, S., Fujita, N., Ishihama, A. and Niki, H. (1996). "Identification of the cpdA gene encoding cyclic 3′,5′-adenosine monophosphate phosphodiesterase in Escherichia coli". J. Biol. Chem. 271: 25423–25429. PMID 8810311. 

Literatura[uredi - уреди]

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