2-oksopropil-KoM reduktaza (karboksilacija)
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| 2-oksopropil-KoM reduktaza (karboksilacija) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.8.1.5 | ||||||||
| CAS broj | 244301-63-1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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2-oksopropil-KoM reduktaza (karboksilacija) (EC 1.8.1.5, NADPH:2-(2-ketopropiltio)etansulfonat oksidoreduktaza/karboksilaza, NADPH:2-ketopropil-koenzim M oksidoreduktaza/karboksilaza) je enzim sa sistematskim imenom 2-merkaptoetansulfonat,acetoacetat:NADP+ oksidoreduktaza (dekarboksilacija).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 2-merkaptoetansulfonat + acetoacetat + NADP+ 2-(2-oksopropiltio)etansulfonat + CO2 + NADPH
Ovaj enzim takođe deluje na tioetre.
Reference[uredi | uredi kod]
- ↑ Allen, J.R., Clark, D.D., Krum, J.G. and Ensign, S.A. (1999). „A role for coenzyme M (2-mercaptoethanesulfonic acid) in a bacterial pathway of aliphatic epoxide carboxylation”. Proc. Natl. Acad. Sci. USA 96: 8432-8437. PMID 10411892.
- ↑ Clark, D.D., Allen, J.R. and Ensign, S.A. (2000). „Characterization of five catalytic activities associated with the NADPH:2-ketopropyl-coenzyme M [2-(2-ketopropylthio)ethanesulfonate] oxidoreductase/carboxylase of the Xanthobacter strain Py2 epoxide carboxylase system”. Biochemistry 39: 1294-1304. PMID 10684609.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.