2-Izopropilmalat sintaza
Prijeđi na navigaciju
Prijeđi na pretragu
| 2-Izopropilmalat sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.3.3.13 | ||||||||
| CAS broj | 9030-98-2 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
2-Izopropilmalat sintaza (EC 2.3.3.13, 3-karboksi-3-hidroksi-4-metilpentanoatna 3-metil-2-oksobutanoatna lijaza (KoA-acetilacija), alfa-izopropilmalatna sintetaza, alfa-izopropilmalatna sintaza, alfa-izopropilmalatna sintetaza, izopropilmalatna sintaza, izopropilmalatna sintetaza) je enzim sa sistematskim imenom acetil-KoA:3-metil-2-oksobutanoat C-acetiltransferaza (tioestarska hidroliza, formiranje karboksimetila).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- acetil-KoA + 3-metil-2-oksobutanoat + H2O (2S)-2-izopropilmalat + KoA
Za dejstvo ovog enzima je neophodan K+.
Reference[uredi | uredi kod]
- ↑ Kohlhaw, G., Leary, T.R. and Umbarger, H.E. (1969). „α-Isopropylmalate synthase from Salmonella typhimurium. Purification and properties”. J. Biol. Chem. 244: 2218-2225. PMID 4976555.
- ↑ Webster, R.E. and Gross, S.R. (1965). „The α-isopropylmalate synthetase of Neurospora. I. The kinetics and end product control of α-isopropylmalate synthetase function”. Biochemistry 4: 2309-2327.
- ↑ Cole, F.E., Kalyanpur, M. (1973). „G. and Stevens, C. M. Absolute configuration of α-isopropylmalate and the mechanism of its conversion to β-isopropylmalate in the biosynthesis of leucine”. Biochemistry 12: 3346-3350. PMID 4270046.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.