2-Amino-1-metil-6-fenilimidazo(4,5-b)piridin

Izvor: Wikipedia
2-Amino-1-metil-6-fenilimidazo(4,5-b)piridin
PhIP
IUPAC ime
Drugi nazivi PhIP
Identifikacija
CAS registarski broj 105650-23-5 YesY
PubChem[1][2] 1530
ChemSpider[3] 1476 YesY
DrugBank DB08398
ChEMBL[4] CHEMBL1213271 YesY=
Jmol-3D slike Slika 1
Svojstva
Molekulska formula C13H12N4
Molarna masa 224.26 g mol−1
Agregatno stanje bela čvrsta materija
Gustina 1,3 gcm−3
Tačka topljenja

300 °C, 573 K, 572 °F

Tačka ključanja

468.9 °C, 742 K, 876 °F

Rastvorljivost u vodi 407,1 mg/L
Opasnost
Opasnost u toku rada T



Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala

Infobox references

PhIP (2-Amino-1-metil-6-fenilimidazo(4,5-b)piridin) jedan je od najzastupljenijih heterocikličnigh amina (HCA) u kuvanom mesu. PhIP se formira na visokim temperaturama reakcijom između kreatina ili kreatinina (prisutnog u mišićnom tkivu), aminokiselina, i šećera. PhIP formiranje se povećava sa povećanjem temperature i dužinom kuvanja, a takođe je zavisno od metoda kuvanja i tipa mesa. Smatra se da može da bude kancirogen.[5][6].[7]

Reference[uredi - уреди]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. doi:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. doi:10.1186/1758-2946-2-3. PMID 20331846.  edit
  4. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. doi:10.1093/nar/gkr777. PMID 21948594.  edit
  5. U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program. (2011). Report on Carcinogens, 12th ed., p. 222.
  6. International Agency for Research on Cancer (IARC) (1997) PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine)(Group 2B). Summaries & Evaluations. http://www.inchem.org/documents/iarc/vol56/08-phip.html
  7. Cross, A., & Sinha, R. (2004) Meat-Related Mutagens/Carcinogens in the Etiology of Colorectal Cancer. Environmental and Molecular Mutagenesis. 44:45-55.