1,8-Cineolna sintaza
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1,8-Cineolna sintaza | |||||||||
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Identifikatori | |||||||||
EC broj | 4.2.3.108 | ||||||||
CAS broj | 110637-19-9 | ||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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1,8-Cineolna sintaza (EC 4.2.3.108, 1,8-cineolna ciklaza, geranilna pirofoshat:1,8-cineolna ciklaza, 1,8-cineolna sintetaza) je enzim sa sistematskim imenom geranil-difosfat difosfat-lijaza (ciklizacija, formira 1,8-cineol).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- geranil difosfat + H2O 1,8-cineol + difosfat
Za dejstvo ovog enzima je neophodan jon Mn2+ ili Zn2+.
Reference[uredi | uredi kod]
- ↑ Croteau, R., Alonso, W.R., Koepp, A.E. and Johnson, M.A. (1994). „Biosynthesis of monoterpenes: partial purification, characterization, and mechanism of action of 1,8-cineole synthase”. Arch. Biochem. Biophys. 309: 184-192. PMID 8117108.
- ↑ Wise, M.L., Savage, T.J., Katahira, E. and Croteau, R. (1998). „Monoterpene synthases from common sage (Salvia officinalis). cDNA isolation, characterization, and functional expression of (+)-sabinene synthase, 1,8-cineole synthase, and (+)-bornyl diphosphate synthase”. J. Biol. Chem. 273: 14891-14899. PMID 9614092.
- ↑ Peters, R.J. and Croteau, R.B. (2003). „Alternative termination chemistries utilized by monoterpene cyclases: chimeric analysis of bornyl diphosphate, 1,8-cineole, and sabinene synthases”. Arch. Biochem. Biophys. 417: 203-211. PMID 12941302.
- ↑ Chen, F., Ro, D.K., Petri, J., Gershenzon, J., Bohlmann, J., Pichersky, E. and Tholl, D. (2004). „Characterization of a root-specific Arabidopsis terpene synthase responsible for the formation of the volatile monoterpene 1,8-cineole”. Plant Physiol. 135: 1956-1966. PMID 15299125.
- ↑ Keszei, A., Brubaker, C.L., Carter, R., Kollner, T., Degenhardt, J. and Foley, W.J. (2010). „Functional and evolutionary relationships between terpene synthases from Australian Myrtaceae”. Phytochemistry 71: 844-852. PMID 20399476.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.