(R)-6-hidroksinikotin oksidaza
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| (R)-6-hidroksinikotin oksidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.5.3.6 | ||||||||
| CAS broj | 37233-46-8 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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(R)-6-hidroksinikotin oksidaza (EC 1.5.3.6, D-6-hidroksinikotinska oksidaza, 6-hidroksi-D-nikotinska oksidaza) je enzim sa sistematskim imenom (R)-6-hidroksinikotin:kiseonik oksidoreduktaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (R)-6-hidroksinikotin + H2O + O2 1-(6-hidroksipiridin-3-il)-4-(metilamino)butan-1-on + H2O2
Ovaj enzim je flavoprotein (FAD).
Reference[uredi | uredi kod]
- ↑ Brühmüller, M., Möhler, H.K. and Decker, K. (1972). „Covalently bound flavin in D-6-hydroxynicotine oxidase from Arthrobacter oxidans. Purification and properties of D-6-hydroxynicotine oxidase”. Eur. J. Biochem. 29: 143-151. PMID 4628374.
- ↑ Decker, K. and Bleeg, H. (1965). „Induction and purification of stereospecific nicotine oxidizing enzymes from Arthrobacter oxidans”. Biochim. Biophys. Acta 105: 313-324. PMID 5849820.
- ↑ Koetter, J.W. and Schulz, G.E. (2005). „Crystal structure of 6-hydroxy-D-nicotine oxidase from Arthrobacter nicotinovorans”. J. Mol. Biol. 352: 418-428. PMID 16095622.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.