(KDO)2-lipid IVA (2-8) 3-dezoksi-D-mano-oktulozonska kiselina transferaza
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| (KDO)2-lipid IVA (2-8) 3-dezoksi-D-mano-oktulozonska kiselina transferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.4.99.14 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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(KDO)2-lipid IVA (2-8) 3-dezoksi-D-mano-oktulozonska kiselina transferaza (EC 2.4.99.14, KDO transferaza, waaA (gen), kdtA (gen), 3-dezoksi-D-mano-okt-2-ulozonska kiselina transferaza, 3-dezoksi-mano-oktulozonska kiselina transferaza) je enzim sa sistematskim imenom CMP-3-dezoksi-D-mano-okt-2-ulozonat:(KDO)2-lipid IVA 3-dezoksi-D-mano-okt-2-ulozonat transferaza ((2->8) formira glikozidnu vezu).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- alfa-Kdo-(2->4)-alfa-Kdo-(2->6)-lipid IVA + CMP-alfa-Kdo alfa-Kdo-(2->8)-alfa-Kdo-(2->4)-alfa-Kdo-(2->6)-lipid IVA + CMP
Enzimi iz Chlamydia prenose tri ili više 3-dezoksi-D-mano-okt-2-ulozonatna ostatka i formiraju genus-specifične epitope.
Reference[uredi | uredi kod]
- ↑ Lobau, S., Mamat, U., Brabetz, W. and Brade, H. (1995). „Molecular cloning, sequence analysis, and functional characterization of the lipopolysaccharide biosynthetic gene kdtA encoding 3-deoxy-α-D-manno-octulosonic acid transferase of Chlamydia pneumoniae strain TW-183”. Mol. Microbiol. 18: 391-399. PMID 8748024.
- ↑ Mamat, U., Baumann, M., Schmidt, G. and Brade, H. (1993). „The genus-specific lipopolysaccharide epitope of Chlamydia is assembled in C. psittaci and C. trachomatis by glycosyltransferases of low homology”. Mol. Microbiol. 10: 935-941. PMID 7523826.
- ↑ Belunis, C.J., Mdluli, K.E., Raetz, C.R. and Nano, F.E. (1992). „A novel 3-deoxy-D-manno-octulosonic acid transferase from Chlamydia trachomatis required for expression of the genus-specific epitope”. J. Biol. Chem. 267: 18702-18707. PMID 1382060.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.