(KDO)-lipid IVA 3-dezoksi-D-mano-oktulozonska kiselina transferaza
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| (KDO)-lipid IVA 3-dezoksi-D-mano-oktulozonska kiselina transferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.4.99.13 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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(KDO)-lipid IVA 3-dezoksi-D-mano-oktulozonska kiselina transferaza (EC 2.4.99.13, KDO transferaza, waaA (gen), kdtA (gen), Kdo transferaza, 3-dezoksi-D-mano-okt-2-ulozonska kiselina transferaza, 3-dezoksi-mano-oktulozonska kiselina transferaza) je enzim sa sistematskim imenom CMP-3-dezoksi-D-mano-okt-2-ulozonat:(KDO)-lipid IVA 3-dezoksi-D-mano-okt-2-ulozonat transferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- alfa-Kdo-(2->6)-lipid IVA + CMP-alfa-Kdo alfa-Kdo-(2->4)-alfa-Kdo-(2->6)-lipid IVA + CMP
Ovaj bifunkcionalani enzim iz Escherichia coli prenosi dva 3-dezoksi-D-mano-okt-2-ulozonatna ostataka na lipid IVA (cf. EC 2.4.99.12 [(KDO)-lipid IVA 3-dezoksi-D-mano-oktulozonska kiselina transferaza]).
Reference[uredi | uredi kod]
- ↑ Belunis, C.J. and Raetz, C.R. (1992). „Biosynthesis of endotoxins. Purification and catalytic properties of 3-deoxy-D-manno-octulosonic acid transferase from Escherichia coli”. J. Biol. Chem. 267: 9988-9997. PMID 1577828.
- ↑ Lobau, S., Mamat, U., Brabetz, W. and Brade, H. (1995). „Molecular cloning, sequence analysis, and functional characterization of the lipopolysaccharide biosynthetic gene kdtA encoding 3-deoxy-α-D-manno-octulosonic acid transferase of Chlamydia pneumoniae strain TW-183”. Mol. Microbiol. 18: 391-399. PMID 8748024.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.