Želatinaza A

Izvor: Wikipedia
želatinaza-a
Identifikatori
EC broj 3.4.24.24
CAS broj 146480-35-5
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

želatinaza-a (EC 3.4.24.24, 72-kDa želatinaza, matriks metaloproteinaza 2, tip IV kolagenaza, 3/4 kolagenaza, matriks metaloproteinaza 5, 72 kDa želatinaža tip A, kolagenaza IV, kolagenaza tip IV, MMP 2, tip IV kolagen metaloproteinaza, tip IV kolagenaza/želatinaza, matriks metaloproteinaza 2) je enzim.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju

Razlaganje želatina tipa I i kolagena tipa IV, V, VII, X. Razlaganje kolagenu sličnih sekvenci Pro-Gln-Gli-Ile-Ala-Gly-Gln

Ova endopeptidaza pripada peptidaznoj familiji M10.

Reference[uredi - уреди]

  1. Murphy, G., McAlpine, C.G., Poll, C.T. and Reynolds, J.J. (1985). "Purification and characterization of a bone metalloproteinase that degrades gelatin and types IV and V collagen". Biochim. Biophys. Acta 831: 49-58. PMID 2994741. 
  2. Collier, I.E., Wilhelm, S.M., Eisen, A.Z., Marmer, B.L., Grant, G.A., Seltzer, J.L., Kronberger, A., He, C., Bauer, E.A. and Goldberg, G.I. (1988). "H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen". J. Biol. Chem. 263: 6579-6587. PMID 2834383. 
  3. Okada, Y., Morodomi, T., Enghild, J.J., Suzuki, K., Yasui, A., Nakanishi, I., Salvesen, G. and Nagase, H. (1990). "Matrix metalloproteinase 2 from human rheumatoid synovial fibroblasts-purification and activation of the precursor and enzymic properties". Eur. J. Biochem. 194: 721-730. PMID 2269296. 

Literatura[uredi - уреди]

Spoljašnje veze[uredi - уреди]