(+)-Alfa-pinenska sintaza
(Preusmjereno sa stranice (+)-alfa-pinen sintaza)
(+)-Alfa-pinenska sintaza | |||||||||
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Identifikatori | |||||||||
EC broj | 4.2.3.121 | ||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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(+)-Alfa-pinenska sintaza (EC 4.2.3.121, (+)-alfa-pinenska ciklaza, ciklaza I) je enzim sa sistematskim imenom geranil-difosfat difosfat-lijaza (ciklizacija, formira (+)-alfa-pinen).[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
- geranil difosfat (+)-alfa-pinen + difosfat
Ciklaza I iz Salvia officinalis formira jednake količine (-)-alfa-pinena i (-)-kamfena.
- ↑ Gambliel, H. and Croteau, R. (1984). „Pinene cyclases I and II. Two enzymes from sage (Salvia officinalis) which catalyze stereospecific cyclizations of geranyl pyrophosphate to monoterpene olefins of opposite configuration”. J. Biol. Chem. 259: 740-748. PMID 6693393.
- ↑ Croteau, R., Satterwhite, D.M., Cane, D.E. and Chang, C.C. (1988). „Biosynthesis of monoterpenes. Enantioselectivity in the enzymatic cyclization of (+)- and (-)-linalyl pyrophosphate to (+)- and (-)-pinene and (+)- and (-)-camphene”. J. Biol. Chem. 263: 10063-10071. PMID 3392006.
- ↑ Wagschal, K.C., Pyun, H.J., Coates, R.M. and Croteau, R. (1994). „Monoterpene biosynthesis: isotope effects associated with bicyclic olefin formation catalyzed by pinene synthases from sage (Salvia officinalis)”. Arch. Biochem. Biophys. 308: 477-487. PMID 8109978.
- ↑ Pyun, H.J., Wagschal, K.C., Jung, D.I., Coates, R.M. and Croteau, R. (1994). „Stereochemistry of the proton elimination in the formation of (+)- and (-)-α-pinene by monoterpene cyclases from sage (Salvia officinalis)”. Arch. Biochem. Biophys. 308: 488-496. PMID 8109979.
- ↑ Phillips, M.A., Savage, T.J. and Croteau, R. (1999). „Monoterpene synthases of loblolly pine (Pinus taeda) produce pinene isomers and enantiomers”. Arch. Biochem. Biophys. 372: 197-204. PMID 10562434.
- ↑ Phillips, M.A., Wildung, M.R., Williams, D.C., Hyatt, D.C. and Croteau, R. (2003). „cDNA isolation, functional expression, and characterization of (+)-α-pinene synthase and (-)-α-pinene synthase from loblolly pine (Pinus taeda): stereocontrol in pinene biosynthesis”. Arch. Biochem. Biophys. 411: 267-276. PMID 12623076.
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